Mito Uzumaki (うずまきミト, Uzumaki Mito) was a kunoichi who originated from's and later married into 's . She was also the first jinchūriki of , the Nine-Tails.
The Uzumaki and Senju clans — being distant relatives — has always had close ties. Mito ended up marrying , who would help found and became the village's First .
During her husband's battle against  Despite the seal's strength, it almost broke at some later point when she was going through childbirth. Eventually, her husband died in war, and Mito was left a widow.at the , Hashirama at some point gained control of . To gain power for her husband, Mito used a fūinjutsu to seal Kurama within herself, becoming the tailed beast's first jinchūriki.
Towards the final years of her life, it was decided that a new host for Kurama would have to be found.  Some time after this, the beast was presumably extracted from within Mito and sealed into Kushina., one of Mito's clansmen, was then selected for the role due to her special chakra. Terrified by the idea of having been taken from her home to become a jinchūriki, Mito comforted her, and before told Kushina that in order to counter the Nine-Tails' hatred, she needed to fill herself with love.
Mito seemed to be a very calm and composed individual with a dignified air about her. She also had a strong sense of duty to her husband and the village as seen when she turned herself into a jinchūriki by sealing the Nine-Tails into herself in order to gain power for her husband. During the time when Kushina discovered that she was to be made a jinchūriki, Mito comforted her, and told her about how to cope with being a jinchūriki.
Mito had long, bright-red hair and large, pupiless eyes. She wore an elaborate, high-collared kimono with the hair pins in them and three clips in the front. She also wore a dark shade of red lipstick and had a violet-coloured diamond mark on her forehead — similar to that of her granddaughter . She also wore tags with kanji written on them in her hair decals. In her old age, her hair had grown much longer some of which she allowed to hang into her back (in the anime her hair was depicted as maroon in her old age). She, however, maintained the two buns in her hair and wore a simple loose fitting kimono held closed by a simple dark-coloured obi.symbol on the back of the obi which was tied around her waist. Her hair was arranged in buns with
Not much is known about her fighting skills, but Kushina hailed her as a powerful kunoichi. She was shown to be exceptional at , being able to seal the entirety of within herself. Also, in becoming a jinchūriki, she had access to extraordinary reserves of strong chakra. Due to being a member of the Uzumaki clan, Mito had the potential to live an exceptionally long life. This was seen in part from her having lived her adult life through the reign of the first three Hokage. Like Naruto, Mito also had the ability to sense negative emotions due to her control over the fox's power.
Mito made great contributions in the way of protecting Konohagakure after becoming the beast's jinchūriki. She was also the one who realised that in order to counter Kurama's ability to overwhelm his jinchūriki with negative emotions, thus taking control of them, love was needed. This was information she passed on to Kushina Uzumaki which in part helped the young woman to be able to subdue the beast within her and later helpedto subjugate the beast.
- Mito's name may be taken from the name of the capital of one of the prefectures in Japan.